Definition: The probability distribution with the highest uncertainty given fixed constraints. Makes the fewest assumptions to avoid bias.

Detonation: “You became the most probable version of yourself:
hope integrated to a constant.”

Definition: Predefined endpoint in survival analysis — death, progression, recovery. Used to calculate hazard ratios and Kaplan-Meier curves.
Detonation: “The blue curve is your soundless jagged drop,
the months you positively suffered."

Definition: Last Observation Carried Forward (LOCF) imputes missing data by carrying the last recorded value forward. Assumes the patient remained stable after dropout.
Detonation: “I impute your silence, your missingness. I calculate the story you should be” 

Definition: Secure Research Environment: a restricted-access space where de-identified data is analyzed under strict rules to prevent corruption or leakage.
Detonation: "One of them is watching me count the dust"

Definition: Data points far outside the expected range. Often viewed as noise to be trimmed, but can signal measurement error or a critical rare event.
Detonation: "and the neighbors can hear your orgasm howls."

Definition: The difference between observed and predicted value. Random scatter suggests good fit; patterns in residuals suggest model failure.
Detonation: “The clock in a room left at 68, counting toward nothing."